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A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells, researchers concluded that the supplement likely protects proteins that build neurons’ cellular skeletons. The supplement betaine was first isolated from sugar beets and is often […]
A new generation of miniature recording probes can track the same neurons inside tiny mouse brains over weeks—and even months. The new tools build on the success of the original Neuropixels probes released in 2017 and currently used in more than 400 labs. Neuropixels 2.0 are much smaller—about a third the size of their predecessors. […]
On the surface, Parkinson's disease -; a neurodegenerative disorder -; and melanoma -; a type of skin cancer -; do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson's disease patients are more likely to develop melanoma than the general population. Now, scientists report a molecular link […]
Many cognitive neurodevelopmental disorders are a result of too many or too few copies of certain genes or chromosomes. To date, no treatment options exist for this class of disorders. MECP2 duplication syndrome (MDS) is one such disorder that primarily affects boys and results from a duplication spanning the methyl-CpG binding protein 2 (MECP2) locus […]
When central nervous system cells in the brain and spine are damaged by disease or injury, they fail to regenerate, limiting the body's ability to recover. In contrast, peripheral nerve cells that serve most other areas of the body are more able to regenerate. Scientists for decades have searched for molecular clues as to why […]
Alstrom syndrome has been the focus of attention, among other ciliopathies, in research on the biological functions of cilia as well as the best mode of treatment of these disorders. The ALMS1 gene has been associated with this condition. Physiological Roles of ALMS1 Protein The ALMS1 gene has been the locus of research because of […]
“Being crabby” might have a whole new meaning. A crab’s nervous system could help scientists learn what causes single neurons in the human brain to become “out of whack,” which can contribute to the development of neurological diseases like Alzheimer’s disease. Knowing exactly how a single neuron operates among the billions housed in the human […]
In a current paper published in the journal Nature, Heidelberg-based researchers and physicians describe how neurons in the brain establish contact with aggressive glioblastomas and thus promote tumor growth / New tumor activation mechanism provides starting points for clinical trials Neurons transmit their signals to each other via synapses, fine cell projections with terminals that […]
Biomedical engineers at Duke University have developed an automated process that can trace the shapes of active neurons as accurately as human researchers can, but in a fraction of the time. This new technique, based on using artificial intelligence to interpret video images, addresses a critical roadblock in neuron analysis, allowing researchers to rapidly gather […]
An anti-smoking drug now has a new job—as a chemical switch to turn select neurons on or off. The drug latches on to designer proteins, called ion channels, that control whether or not a neuron will send a message. By putting those proteins only in certain groups of neurons, scientists can target modulation of specific […]