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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by an interaction between the human angiotensin-converting enzyme type 2 (ACE2) receptor and the SARS-CoV-2 spike (S) protein. This interaction closely resembles the mechanism of infection by SARS-CoV, the causative agent of SARS. However, in comparison, the interaction of the S1 subunit of SARS-CoV-2 with […]
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by an interaction between the human angiotensin-converting enzyme type 2 (ACE2) receptor and the SARS-CoV-2 spike (S) protein. This interaction closely resembles the mechanism of infection by SARS-CoV, the causative agent of SARS. However, in comparison, the interaction of the S1 subunit of SARS-CoV-2 with […]
Researchers in the United States have developed a new model for testing mutations in the four structural proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). Testing of the proteins for their effects on viral assembly, packaging and host cell entry provided a previously unanticipated explanation […]
In the setting of potentially reduced vaccine efficacy against coronavirus disease (COVID-19) due to emerging viral variants, the deployment of effective treatments based on monoclonal antibodies may be an additional strategy to help control the pandemic. A new study by US researchers, currently available on the bioRxiv* preprint server, describes the action of a specific […]
A new study led by Hans-Martin Jäck of the Friedrich-Alexander University Erlangen-Nuremberg in Germany engineered clusters of neutralizing monoclonal antibodies using a transgenic mouse model. A unique characteristic for the antibodies was the different ways it bound to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the overall reduction in the viral spread for […]
Researchers at Erasmus University Medical Center in The Netherlands have explored how and why new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), have exhibited heightened infectivity. Study: Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants. Image Credit: Design_Cells / Shutterstock They suggest […]