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Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell "poor" to T cell […]
Antibodies are central to infection control and prolonged immunity. Key tools in biomedical research, antibodies are also used to diagnose human diseases and detect adaptive immunity to past infections with particular pathogens. While existing methods to discover and generate antibodies are successful, they also have important limitations, such as hard targets (short-lived, homologous, or unstable) […]
Rituximab, an anti-cancer drug targeting the membrane protein CD20, was the first approved therapeutic antibody against B tumor cells. Immunologists at the University of Freiburg have now solved a mystery about how it works. A team headed by Professor Dr. Michael Reth used cell cultures, healthy cells, and cells from cancer patients to investigate how […]
Multiplex immunoassays and enzyme-linked immunosorbent assays (ELISA) are used to determine and analyze the presence of an analyte in a sample through the binding of complimentary antigen-antibody pairs. Multiplex immunoassays are useful in cases of limited sample volume or time. molekuul_be | Shutterstock Multiplex immunoassays can be differentiated by the surface to which the antigens […]
The U.S. Food and Drug Administration has authorized a new, rapid antigen test for COVID-19, which costs $5 and can diagnose an infection in 15 minutes. The test, made by Abbott Labs, is the size of a credit card and does not require any lab equipment to run. Rather, the device has a similar design […]
Like most other countries, Austria—as part of the Eurotransplant organization—allocates organs to patients on the liver transplant waiting list on the basis of medical urgency. Currently, patients are listed according to urgency using a score made up of three laboratory parameters—the Model for End Stage Liver Disease (MELD) score. However, the MELD score has obvious […]