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Scientists at The University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells. Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn’t return years later — giving peace of […]
Radiotherapy, a common treatment for cancer, is one of the most effective ways to destroy cancer cells and shrink tumours. Around 50% of patients with tumours located in the gastrointestinal cavity (liver, pancreas, colon, prostate, etc) receive this type of treatment, which has increased cancer survival rates over the past decades. However, intensive radiation therapy […]
Ovarian cancer is usually diagnosed only after it has reached an advanced stage, with many tumors spread throughout the abdomen. Most patients undergo surgery to remove as many of these tumors as possible, but because some are so small and widespread, it is difficult to eradicate all of them. Researchers at MIT, working with surgeons […]
The field of materials science has become abuzz with “metal-organic frameworks” (MOFs), versatile compounds made up of metal ions connected to organic ligands, thus forming one-, two-, or three-dimensional structures. There is now an ever-growing list of applications for MOF, including separating petrochemicals, detoxing water from heavy metals and fluoride anions, and recovering hydrogen or […]
Human cells have a sophisticated regulatory system at their disposal: labeling proteins with the small molecule ubiquitin. In a first, a team from the Technical University of Munich (TUM) has succeeded in marking proteins with ubiquitin in a targeted manner, in test tubes as well as in living cells. The procedure opens the door to […]
Many types of cancer could be more easily treated if they were detected at an earlier stage. MIT researchers have now developed an imaging system, named “DOLPHIN,” which could enable them to find tiny tumors, as small as a couple of hundred cells, deep within the body. In a new study, the researchers used their […]
A City of Hope scientist and his colleagues have developed a user-friendly approach to creating “theranostics” — therapy combined with diagnostics — that target specific tumors and diseases. Key to the process are molecules called metallocorroles, which serve as versatile platforms for the development of drugs and imaging agents. City of Hope’s John Termini, Ph.D., […]
Tissues and organs in the human body are shaped through forces generated by cells, that push and pull, to “sculpt” biological structures. Thanks to a new tool developed at McGill University, scientists will now be able to watch, and map these forces. Christopher Moraes, an assistant professor in McGill’s Department of Chemical Engineering, and colleagues […]
In a new invited review article, ASU Biodesign microbiologists and tissue engineers Cheryl Nickerson, Jennifer Barrila and colleagues discuss the development and application of three-dimensional (3-D) tissue culture models as they pertain to infectious disease. They describe these models as predictive pre-clinical platforms to study host-pathogen interactions, infectious disease mechanisms, and antimicrobial drug development. The […]
Using tiny micromotors to diagnose and treat disease in the human body could soon be a reality. But keeping these devices intact as they travel through the body remains a hurdle. Now in a study appearing in ACS Nano, scientists report that they have found a way to encapsulate micromotors into pills. The pill’s coating […]