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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions worldwide, causing respiratory coronavirus disease 2019 (COVID-19) and a global pandemic. Rapid development and deployment of different COVID-19 vaccines and non-pharmaceutical interventions, such as hard and soft lockdowns, have been effective in curbing numbers of daily new infections, hospitalizations, and deaths globally. However, while vaccines […]
A team led by scientists at Baylor College of Medicine uncovered new evidence supporting a cancer-promoting role for enzyme MAPK6. The study, published in the journal Science Advances, shows that MAPK6 furthers cancer growth by activating the AKT pathway, a known cancer-promoting cellular mechanism. The findings suggest that therapies directed at interfering with MAPK6 activity […]
Researchers at Weill Cornell Medicine have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects. The results illuminate one of the central problems of drug discovery and point to new strategies for solving it. Any class of drug can have side effects, but those that […]
According to a recent study published in Advanced Materials Technologies, electrically controllable DNA nanolevers may be an effective tool in learning more about the flu virus. German scientists used DNA nanolevers to target the interaction between a peptide known as PeB and influenza A. Study: Measuring Influenza A Virus and Peptide Interaction Using Electrically Controllable […]
Researchers from the INCLIVA Health Research Institute, the Clinical Hospital of Valencia, and the University of Valencia (UV) have participated in a study, the results of which have just been published in Science, which paves the way for a better understanding of muscle injury. The work will enable, in the future, the application of interventions […]
Researchers from the Agency for Science, Technology and Research's (A*STAR) Genome Institute of Singapore (GIS), and Rady Children's Institute for Genomic Medicine identified a previously unknown condition affecting children, which they discovered could be prevented by administering a drug during pregnancy. Through a worldwide collaboration, the researchers identified children from Egypt, India, United Arab Emirates, […]
The mortality rate of COVID-19 patients requiring mechanical ventilation is 30-40%, however, the immunological factors associated with death in critically ill COVID-19 patients are poorly understood. A study published in PLOS Pathogens by Jonathan Youngs at St. George’s University of London, United Kingdom and colleagues suggests an association between systemic inflammation responses and increased mortality […]
Many diseases have their origin in early human development, and today (8th September), two publications in Nature reveal how researchers from the Human Cell Atlas (HCA) consortium are advancing understanding of this. The global HCA initiative is mapping every cell type in the human body, to transform our knowledge of biology, infection and disease. A […]
Bats have long been known as important hosts of zoonotic viral pathogens. Zoonotic viruses that bats transmit are capable of infecting humans and have caused devastating infections throughout the world. Common zoonotic viruses include the Ebola virus and the severe acute respiratory syndrome (SARS) coronaviruses. Although retroviruses are known to have a major global impact […]
From the time of Aristotle, it has been known that the human liver has the greatest regenerative capacity of any organ in the body, being able to regrow even from a 70% amputation, which has enabled live-donor transplants. Although the liver regenerates fully upon injury, the mechanisms that regulate how to activate or stop the […]