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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by an interaction between the human angiotensin-converting enzyme type 2 (ACE2) receptor and the SARS-CoV-2 spike (S) protein. This interaction closely resembles the mechanism of infection by SARS-CoV, the causative agent of SARS. However, in comparison, the interaction of the S1 subunit of SARS-CoV-2 with […]
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by an interaction between the human angiotensin-converting enzyme type 2 (ACE2) receptor and the SARS-CoV-2 spike (S) protein. This interaction closely resembles the mechanism of infection by SARS-CoV, the causative agent of SARS. However, in comparison, the interaction of the S1 subunit of SARS-CoV-2 with […]
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions worldwide, causing respiratory coronavirus disease 2019 (COVID-19) and a global pandemic. Rapid development and deployment of different COVID-19 vaccines and non-pharmaceutical interventions, such as hard and soft lockdowns, have been effective in curbing numbers of daily new infections, hospitalizations, and deaths globally. However, while vaccines […]
Horseshoe bats (Rhinolophus sp.) are known reservoirs of zoonotic coronaviruses (CoVs). Over the last twenty years, viruses thought to have originated from these bats have given rise to two severe acute respiratory syndrome (SARS) epidemic outbreaks in humans: SARS-CoV-1 in 2002/2003, which was limited mostly to Asia, and the currently globally circulating SARS-CoV-2, first identified […]