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A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer’s disease. As published today in the Royal Society of Chemistry’s Chemical Communications, the compound—known as “C1″—uses a novel mechanism to efficiently prevent the enzyme gamma-secretase […]
Lyme disease is caused by four main species of bacteria. Borrelia burgdorferi and Borrelia mayonii cause Lyme disease in the United States, while Borrelia afzelii and Borrelia garinii are the leading causes in Europe and Asia. The most common tick-borne illness in these regions, Lyme disease is transmitted by the bite of an infected black-legged […]
A study led by Nikhil Reddy, a second-year student at the Wright State University Boonshoft School of Medicine, has charted a protein’s decline through the progression of Barrett’s esophagus disease. The sickness, typically occurring after long-term acid reflux, is associated with a significant increase in the risk for esophageal cancer later in life. The protein, […]
Girl, two, is the only person in the WORLD to have a type of ‘Benjamin Button’ disease as her father reveals he calls her GRANDMA Isla Kilpatrick-Screaton has a unique type of mandibuloacral dysplasia The two-year-old, from Leicester, weighs only 15lbs (7kg) and uses sign language Her condition makes her cells age faster than normal, […]
There are a few things you probably don’t know about heart disease, especially how it affects women. Heart disease is the number one killer of women, but until recently, as Dr. Karen Latimer explains, cardiac issues were thought to be a men’s health problem. The truth is that more women die from heart disease than men. In fact, […]
A critical question in medicine asks how individual variation in DNA can predict variation in health and disease. New research from the Clemson Center for Human Genetics identified hundreds of metabolites that might serve as intermediates to translate variation in the genome to variation in complex traits. Published recently in Genome Research, the findings could one day […]
A multicenter group of 41 hospitals led by researchers at Children’s Hospital of Philadelphia (CHOP) has confirmed that an improved method for predicting retinopathy of prematurity (ROP), a leading cause of blindness in children, was able to reduce the number of babies having invasive diagnostic examinations by nearly a third, while raising disease detection up […]
Bacteriophages (phages) are viruses that specifically destroy bacteria. In the early 20th century, researchers experimented with phages as a potential method for treating bacterial infections. But then antibiotics emerged and phages fell out of favor. With the rise of antibiotic-resistant infections, however, researchers have renewed their interest in phage therapy. In limited cases, patients with […]
Scientists are increasingly tracing a variety of diseases back to the so-called epigenome, a type of indexing system imposed on DNA that dictates how genes should be read by the cells. Now, a new study finds that changes in two epigenetics mechanisms—DNA and histone methylation—may interact to spur disease. The scientists looked at two developmental […]
A University of Dundee discovery has the potential to help scientists better understand neurological diseases such as Alzheimer’s and Parkinson’s. Researchers, led by Professor Daan van Aalten in the University’s School of Life Sciences, have developed a new way to tag proteins in human cells with a small sugar molecule called O-GlcNAc. There are over […]