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River blindness and elephantiasis are debilitating diseases caused by parasitic worms that infect as many as 150 million people worldwide. They are among the “neglected tropical diseases” for which better treatments are desperately needed. But they were far from the mind of cell biologist William Sullivan when he began studying the microbial parasite Wolbachia, best […]
EPFL scientists have discovered two small-molecule compound series that can effectively block a central pathway of the innate immune system, offering a promising new way for treating autoinflammatory diseases. The study is published in Nature. The innate immune system is the first line of defense, with cells that quickly identify “foreign” motifs from viruses and […]