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A new preclinical study by University at Buffalo researchers reveals the genetic basis of relapse, one of the most detrimental but poorly understood behaviors related to addiction. Craig Werner, Ph.D., is first author on a paper published Oct. 9 in Science Advances that demonstrates how prolonged abstinence after cocaine use drives gene changes that promote […]
A small segment of a human gene STING, stimulator of interferon genes, could hold the key to treating autoimmune diseases and cancer, according to a study by Texas A&M AgriLife Research scientists. Dr. Pingwei Li, AgriLife Research biochemist and structural biologist, College Station; post doctorates Drs. Baoyu Zhao, and Fenglei Du and graduate student Pengbiao […]
Isabelle Richard’s team, a CNRS researcher in an Inserm unit at Genethon, the AFM-Telethon laboratory, has demonstrated the efficacy of gene therapy and determined the effective dose for treating a rare muscle disease, gamma-sarcoglycanopathy, in mouse models of the disease. Based on these encouraging results, published in Molecular Therapy: Methods and Clinical Development, the researchers […]
Should researchers put the brakes on genetically engineering babies? Leading scientists and ethicists recently called for a moratorium on clinical applications of germline gene editing: inheritable alterations to the DNA of embryos to improve kids’ health or other features – or just “gene editing,” for short. This declaration was prompted in part by the birth […]
Approximately 98 percent of the human genome is made up of noncoding DNA, including enhancers, promoters, and other elements that regulate gene activity. The methods for studying these regions tend to be expensive, labor-intensive, and largely low-throughput. To really understand the functional geography of the noncoding genome, however, researchers need a way to isolate and […]
Genome editing technology is helping A*STAR scientists unravel how the Influenza A virus (IAV) exploits human anti-viral responses. IAV remains a key challenge for global health resources, not least because of wide variations in symptom severity experienced by different people, even when they are infected by the same strain. This implies that there are host […]
FRIDAY, Oct. 26, 2018 — Athletes may be less likely to suffer concussions if they carry a gene linked to the learning disorder dyslexia, a new study suggests. Researchers looked at the concussion history of 87 football players at Penn State University. They also checked the players for certain genes. The findings suggest that “genotype […]
A drug could help slow the progression of some advanced ovarian cancers and extend the time that patients show no signs of disease, according to new clinical trial results. The study, published in the New England Journal of Medicine, found that the drug olaparib (Lynparza) could delay the return of advanced ovarian cancer in some […]
One of the deadliest skin cancers, melanoma may be caused by overexposure to ultraviolet radiation from the sun or artificial sources such as tanning beds and sunlamps. The Melanoma Network of Canada reports that lifetime risk for developing melanoma has increased to one in 63 people today—up from one in 1,500 in the 1930s. “It […]
A single gene from the mother plays such a crucial role in the development of the placenta that its dysfunction leads to miscarriages. Researchers from the Medical Faculty of Ruhr-Universität Bochum (RUB) have observed this in so-called knockout mice that were specifically modified for this purpose. These mice lack the gene for the transcription factor […]