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The essential malaria drug artemisinin acts like a “ticking time bomb” in parasite cells—but in the half a century since the drug was introduced, malaria-causing parasites have slowly grown less and less susceptible to the treatment, threatening attempts at global control over the disease. In a paper published September 23 in Nature Communications, Whitehead Institute […]
Australian researchers from QIMR Berghofer Medical Research Institute have shown that 22 different genes help to determine how much sun exposure a person needs to receive before developing melanoma. For people at high genetic risk, sun exposure in childhood is a strong contributing factor while people at low genetic risk develop melanoma only after a […]
A team of neuroscientists led by Professor Christiana Ruhrberg (UCL, UK) and Professor Anna Cariboni (University of Milan, Italy) have found two molecules that work together to help set up the sense of smell and pave the way to puberty in mice. These findings, reported in the journal Development, may help our understanding of why […]
Any effect that assisted reproduction technology has on babies’ genes is largely corrected by adulthood, new research led by the Murdoch Children’s Research Institute has found. Published in the latest edition of Nature Communications, the study found events that occur in early development, including ovarian stimulation, manipulation of the embryo and the extra hormones common […]
The expression of many genes that have previously been associated with autism is abnormal also in violent psychopathy, a new study shows. The researchers used stem cell technology to analyse the expression of genes and proteins in the brain cells of psychopathic violent offenders. Published in Molecular Psychiatry, the findings may open up new avenues […]
Pluripotent cells can give rise to all cells of the body, a power that researchers are eager to control because it opens the door to regenerative medicine and organ culture for transplants. But pluripotency is still a black box for science, controlled by unknown genetic (expression of genes) and epigenetic signals (biochemical marks that control […]
Semiconducting polymers, very large chain-like molecules made from repeating sub-units, are increasingly drawing the attention of researchers because of their potential applications in organic electronic devices. Like most semiconducting materials, semiconducting polymers can be classified as p-type or n-type according to their conducting properties. Although p-type semiconducting polymers have seen dramatic improvements thanks to recent […]
Neurodevelopmental disorders arising from rare genetic mutations can cause atypical cognitive function, intellectual disability, and developmental delays, yet it is unclear why and how this happens. Scientists suspected a mutation in a complex of proteins could be the culprit for a group of rare genetic disorders and, now, Salk Institute researchers have identified the molecular […]
Ribosomes, the essential machinery used for protein synthesis is recycled after each one round of translation. An enzyme called ABCE1 is responsible for this process and turns out to be remarkably plastic as Ludwig-Maximilians-Universitaet (LMU) in Munich biophysicists report. Ribosomes translate the genetic information, which is first transcribed into messenger RNAs by polymerases, into the […]
A new discovery by researchers at Columbia University Vagelos College of Physicians and Surgeons could fix one of the major shortcomings of current gene-editing tools, including CRISPR, and offer a powerful new approach for genetic engineering and gene therapy. Their new technology, called INTEGRATE, harnesses bacterial jumping genes to reliably insert any DNA sequence into […]