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The human gut microbiota largely reaches an adult-like composition by five years of age, but important differences remain, finds a study published on March 31st in the journal Cell Host & Microbe. Several bacterial taxa that have been associated with human health are acquired late in childhood and have not reached their adult abundance by […]
Parkinson’s disease (PD) is treated by levodopa, which is a prodrug capable of crossing the blood-brain barrier before being metabolized to dopamine, a vital neurotransmitter in the brain. However, certain gut bacteria interfere with this treatment, leading to unpredictable fluctuations in the motor response to levodopa and pushing up the dosage levels unnecessarily. Image Credit: […]
A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Breast tissue cells exposed to this […]
A team of researchers from several institutions in China, and two in the U.S. reports a link between human gut microbiome disturbances and major depressive disorder (MDD). In their paper published in the journal Science Advances, the group describes their study of fecal samples from MDD patients and control groups. MDD is a mood disorder […]
The gut’s microbiome—a complex, dense mixture of bacteria, fungi, and other microbes—plays an integral role in human health. A new Yale study reveals just how early the microbiome is formed and begins delivering this benefit. For the first time, Yale scientists report that components of the gut microbiome begin to mature in utero, much earlier […]
A new study from Lawson Health Research Institute and Western University illustrates how the gut microbiome interacts with an oral medication in prostate cancer patients, suggesting bacteria in the gut play a role in treatment outcomes. The findings, published in Nature Communications, highlight how the drug abiraterone acetate is metabolized by bacteria in the gut […]
Media reports earlier this week described a Queensland nurse with stomach pains who went on to test positive for COVID-19. Could stomach pains be another symptom of COVID-19? And if you have stomach pains, should you get tested? Although we might think of COVID-19 as a respiratory disease, we know it involves the gut. In […]
The cotransporter NKCC1 moves sodium, potassium and chloride ions across the cell membrane of many cell types, including intestinal epithelial cells. Two patients with mutations in NKCC1 suffered from severe intestinal dysfunction and chronic infections. To explore the cellular and molecular mechanisms underlying the role of NKCC1 in the intestinal pathology, Eric Delpire, Ph.D., and […]
Get your gut in great shape: From sitting up straight at the table to lavender milk before bed, experts’ top 20 tips on how to avoid bloating, irritable bowel syndrome and a sluggish stomach Today, the fourth part of our 100 health secrets series opens the kitchen cupboards to reveal small changes that will overhaul […]
A UC Davis study found that the damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus, was rapidly repaired within five hours of receiving Lactobacillus plantarum bacteria. The study, published today in the PNAS, linked chronically inflamed leaky gut to the loss of PPARα signaling […]