Targeting specific areas of the measles virus polymerase, a protein complex that copies the viral genome, can effectively fight the measles virus and be used as an approach to developing new antiviral drugs to treat the serious infectious disease, according to a study by the Institute for Biomedical Sciences at Georgia State University published in […]
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Heavy drinking and HIV don’t mix, study finds
Heavy alcohol consumption (three drinks or more/day for women and four drinks or more/day for men) is linked to alterations in immune function among people with HIV. While it has been known that alcohol impacts immune function, it’s been unclear the effect of alcohol on immune function in the context of HIV, a disease whose […]
Scientists uncover binding secret behind protein ‘superglue’: Mechanism found in Chinese herb helps to create lab-grown enzymes that may speed up drug development
Scientists from Nanyang Technological University, Singapore (NTU Singapore) have pinpointed how a special class of plant-derived enzymes, known as peptide ligases, work to join proteins together. Such binding is an important process in the development of drugs, for example in specifically attaching a chemotherapy drug to an antibody that recognises tumour markers to target cancer […]
Developing a vaccine against Nipah virus
Nipah virus is a type of RNA virus transmitted from animals to humans. The infection causes severe respiratory illness and symptoms including cough, headache and fever, which can progress into encephalitis, seizure and coma. Currently, there is no approved vaccine against Nipah virus available on the market. In recent years, outbreaks, from bat-to-human or pig-to-human […]
Being HIV positive and staying on antiretroviral therapy in Africa
An international team of researchers have carried out a review of the evidence examining what influences people who are HIV positive to go to health services and then stay on antiretroviral drugs in Africa. In a paper published in the Journal PLOS One the team, led by LSTM’s Professor Paul Garner, used advanced methods of […]
The science is clear: with HIV, undetectable equals untransmittable
In recent years, an overwhelming body of clinical evidence has firmly established the HIV Undetectable = Untransmittable (U=U) concept as scientifically sound, say officials from the National Institutes of Health. U=U means that people living with HIV who achieve and maintain an undetectable viral load — the amount of HIV in the blood — by […]
Half a million tests and many mosquitoes later, new buzz about a malaria prevention drug
Most malaria drugs are designed to reduce symptoms after infection. They work by blocking replication of the disease-causing parasites in human blood, but they don’t prevent infection or transmission via mosquitoes. What’s worse, the malaria parasite is developing resistance to existing drugs. “In many ways, the search for new malaria drugs has been a search […]
A new aspect in Plasmodium falciparum life cycle revealed: ‘Express’ sexual conversion: Conversion from the asexual to the sexual phase of the malaria parasite is necessary for its transmission to the mosquito
A study led by the Barcelona Institute for Global Health (ISGlobal) — an institution supported by “la Caixa” Foundation- reveals a new mechanism by which the malaria parasite Plasmodium falciparum converts from its asexual to its sexual form, which can be transmitted to the mosquito. The results, published in Nature Microbiology, provide important information on […]
Strategic plan to address tuberculosis research
Tuberculosis (TB) is the leading infectious cause of death worldwide, killing roughly 1.6 million people in 2017. In the past 200 years, TB claimed the lives of more than one billion people — more deaths than from malaria, influenza, smallpox, HIV/AIDS, cholera and plague combined. Recently, the global health community has strengthened its efforts and […]
Whole blood test for toxoplasmosis is sensitive, specific
Transmission of toxoplasmosis from mother to fetus can lead to severe congenital problems and fetal death, and tests for the parasitic infection during pregnancy are critical. Now, researchers reporting in PLOS Neglected Tropical Diseases have showed the efficacy of a low-cost whole blood test for toxoplasmosis. Toxoplasmosis results from infection with the Toxoplasma gondii parasite, […]