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An immunotherapy based on supercharging the immune system’s natural killer cells has been effective in treating patients with recurrent leukemia and other difficult to treat blood cancers. Now, researchers at Washington University School of Medicine in St. Louis have shown in preclinical studies conducted in mice and human cells that this type of cell-based immunotherapy […]
NEW YORK (Reuters Health) – In patients with non-small cell lung cancer brain metastases (NSCLCBM) treated with immune-checkpoint inhibitors (ICIs) and upfront steroids, a low neutrophil-to-lymphocyte ratio (NLR) was associated with lower overall survival in a single-center retrospective analysis. “With widespread implementation of ICIs for treatment of NSCLC, many clinicians have concerns that the immunosuppressive […]
Skip to: What is AIT? Mechanism of action of AIT Does AIT actually work? Does AIT cause side effects? How is AIT carried out? Allergy immunotherapy or immune therapy (AIT) is used to treat many allergic conditions. About 50 million people experience allergies every year in the US alone, of which about 3 million are […]
Skip to: What are tumorspheres? Tumorsphere formation assay Technical notes on tumorsphere cultivation What are the types of cancer stem cell (CSC) tumorspheres? Tumorspheres for screening anti-CSC drugs What is the future of tumorspheres? What are tumorspheres? Numerous studies have pointed out that cancer stem cells (CSCs) play an important role in cancer progression, metastasis, […]
UT Southwestern scientists have developed a new method to study the molecular characteristics of T cells, critical immune cells that recognize and attack invaders in the body such as viruses, bacteria, and cancer. The approach, described today in the journal Nature Methods, enables researchers to more easily analyze the roles of T cell receptors (TCRs)—the […]
Researchers have created a mathematical model that can determine the impact of the immune system on tumor evolution. The information gained from using this model may be able to be used to predict whether immunotherapy is likely to be effective for a patient’s cancer, helping to guide treatment decisions. Immune cells recognize tumors by detecting […]
Doctors fear immunotherapy could actually make cancer WORSE: For many the treatment is a lifeline, but one airport worker, 31, believes it has handed him a death sentence Joseph McMullan, 31, was one of first British patients to receive CAR-T therapy The therapy is meant to turbo-charge immune system to destroy tumour cells Sadly, CAR-T didn’t […]
A combination of two immunotherapy drugs, ipilimumab and nivolumab, has stopped or reversed the progression of advanced melanoma for five years or more in one in two patients, according to a study led by The Royal Marsden NHS Foundation Trust. Just 10 years ago, only 1 in 20 patients with advanced melanoma would survive for […]
Harnessing the body’s immune system to fight off cancer, a tactic known as immunotherapy, has tremendously improved outcomes for patients. But a lingering problem with immunotherapy, as with many other cancer treatments, is relapse. In many cases the tumor comes back, and doctors don’t know why. Now, research from the lab of Elaine Fuchs, Rockefeller’s […]
(HealthDay)—The U.S. Food and Drug Administration has given its blessing to the first immunotherapy regimen for breast cancer. The combination of immunotherapy (Tecentriq) and chemotherapy (Abraxane) was given accelerated approval for triple-negative breast cancer that is locally advanced or has metastasized, cannot be surgically removed, and is programmed death-ligand 1-postive, CNN reported. A study published […]