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Intestinal epithelial tight junctions (TJs) act as a functional and structural barrier against harmful antigens that promote intestinal inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut. A defective intestinal TJ barrier, sometimes known as “leaky gut,” plays an important role in exacerbating and prolonging intestinal inflammation. New research reported in […]
Intestinal epithelial tight junctions (TJs) act as a functional and structural barrier against harmful antigens that promote intestinal inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut. A defective intestinal TJ barrier, sometimes known as “leaky gut,” plays an important role in exacerbating and prolonging intestinal inflammation. New research reported in […]
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery. This month, a team of scientists and clinicians led by the University of Toronto’s Faculty of Dentistry say they’ve found the reason why—and […]
A group of researchers from Charité–Universitätsmedizin Berlin has discovered a new mechanism of long-lasting pain relief. The cell-signaling protein interleukin-4 induces a specific type of blood cell to produce endogenous opioids at the site of inflammation. The researchers’ findings have been published in the Journal of Clinical Investigation (JCI) Insight. Peripheral nerve inflammation can lead […]
(HealthDay)—Patients with inflammatory bowel disease (IBD) have increased risk of type 2 diabetes, according to a study published online Aug. 5 in Clinical Gastroenterology and Hepatology. Tine Jess, M.D., from the Bispebjerg and Frederiksberg Hospital in Copenhagen, Denmark, and colleagues conducted a nationwide population-based cohort study involving 6,028,844 persons in Denmark to examine the long-term […]
Microbes colonize all body surfaces and balance the immune system. In newborn infants, the gut microbiome is first conditioned by breast milk components. When solid food is introduced, gut microbiota develops and bacteria proliferate. Scientists from the Institut Pasteur and Inserm have discovered that a key immune response is generated in mice when solid food […]
Cancer patients are known to have an increased risk of thrombosis. As part of the CATS study, MedUni Vienna researchers have now investigated a correlation between an activated immune system in cancer patients and their risk of thrombosis. It was found that citrullinated histone 3, known as “H3Cit”, a protein released into the blood by […]
With an estimated 1.6 million people in the U.S. dealing with inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report in the journal JCI Insights finding an epigenetic signature in patient cells […]