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Congenital hepatic fibrosis (CHF) is a rare genetic disease that causes malformation and fibrosis (scarring) of the liver. Occurring in roughly one out of every 20,000 births, CHF can lead to an enlarged liver, impaired blood flow to the intestines (portal hypertension), infection of the bile ducts and liver failure. In severe cases, a liver […]
Liver cells have an innate resistance to RNA viral infections like hepatitis A, dengue and Zika thanks to a protein called IRF1, according to researchers at the University of North Carolina at Chapel Hill (UNC) and Tokyo Metropolitan Institute of Medical Science (TMIMS). When present in liver cells, this IRF1 protein regulates RARRES3, an enzyme […]
Blood platelets that interact with liver cells and immune cells play a major role in the development of fatty liver disease, non-alcoholic fatty liver inflammation and liver cancer, scientists from the German Cancer Research Center (DKFZ) in Heidelberg and from Zurich University and University Hospital have now shown in a publication. The researchers have also […]
Scientists from Georgetown University School of Medicine in Washington, D.C., found that raising production of the protein caused obese mice to reduce the amount of fat in their bodies even though they were genetically engineered to overeat. They did this by increasing expression of the protein’s associated gene. In a paper on their work that […]
Little girl saved – by an HIV-infected liver: World first as doctors transplant organ from HIV-positive mother into her daughter in a desperate bid to cure her end-stage liver failure Nearly every nation in the world faces a critical organ shortage Antiretroviral therapies and PrEP have rendered HIV a manageable infection A little girl in […]
A review article published in the New England Journal of Medicine discusses the effects of alcohol use on various forms of liver disease, as well as the assessment and treatment of alcohol use in patients with chronic liver disease. Liver-related mortality is increasing worldwide, due in large part to the increase in alcohol consumption. This […]
A study led by researchers from the Texas A&M University System and Central Texas Veterans Health Care System, or CTVHCS, shows how a protein known as STING could be a therapeutic target for non-alcoholic fatty liver disease, or NAFLD. The study, “Expression of STING Is Increased in Liver Tissues from Patients with NAFLD and Promotes […]
Nonalcoholic fatty liver disease, or NAFLD, which affects roughly 100 million Americans, costs the United States healthcare system $32 billion annually, according to a first-of-its-kind study by Intermountain Healthcare researchers on the economic impact of the disease. The prevalence of nonalcoholic fatty liver disease mirrors the rising trend of obesity in the United States. Globally, […]