When bacteria or viruses enter the body, proteins on their surfaces are recognized and processed to activate T cells, white blood cells with critical roles in fighting infections. During T-cell activation, a molecular complex known as the microtubule-organizing center (MTOC) moves to a central location on the surface of the T-cell. Microtubules have several important […]
Breast cancer cells become invasive by changing their identity
Researchers from Karolinska Institutet in Sweden have identified a protein that determines the identity and invasive properties of breast cancer cells. The finding could lead to the development of new therapeutic and diagnostic strategies to target breast cancer invasion and metastasis. The study is published in the scientific journal Cancer Research. Cancer cell invasion of […]
New platform based on biology and nanotechnology carries mRNA directly to target cells: Combined platform provides safe, effective passage for therapies treating cancer and other diseases, researchers say
Delivering an effective therapeutic payload to specific target cells with few adverse effects is considered by many to be the holy grail of medical research. A new Tel Aviv University study explores a biological approach to directing nanocarriers loaded with protein “game changers” to specific cells. The groundbreaking method may prove useful in treating myriad […]
Imaging collaboration sheds new light on cancer growth
Walter and Eliza Hall Institute researchers have uncovered new insights into how the normal controls on cell growth are lost in cancer cells, leading to rapid tumour expansion. The findings could help researchers predict how cancer cells respond to chemotherapy and improve our understanding of how cancer evolves. Published in the journal Cell Cycle, the […]
Glow-in-the-dark paper as a rapid test for infectious diseases
Researchers from Eindhoven University of Technology (The Netherlands) and Keio University (Japan) present a practicable and reliable way to test for infectious diseases: All you need are a special glowing paper strip, a drop of blood and a digital camera, as they write in the scientific journal Angewandte Chemie. Not only does this make the […]
The immune system of the alpaca reveals a potential treatment for cancer
The natural world often provides the answer to unsolved medical problems. On this occasion, the solution to a challenge posed by cancer has come about from the immune system of camelids. A study headed by the Institute for Research in Biomedicine (IRB Barcelona) and the Vrije Universiteit Brussel (VUB), in Belgium, describes a number of […]
Doctors issue caution over missed cancer diagnoses tied to immune disorder: Study shows HLH diagnosis may obscure underlying malignancies
Physicians who specialize in a devastating and aggressive immune disorder called hemophagocytic lymphohistiocytosis (HLH) report in a new study that extra care should be taken to ensure an HLH diagnosis doesn’t obscure possible underlying cancers. Because HLH is dangerously aggressive in its progression and attack on vital organs — often causing death — doctors frequently […]
Disrupting genetic processes reverses aging in human cells
Research has shed new light on genetic processes that may one day lead to the development of therapies that can slow, or even reverse, how our cells age. A study led by the University of Exeter Medical School has found that certain genes and pathways that regulate splicing factors — a group of proteins in […]
Heart attack: Substitute muscle thanks to stem cells
Myocardial infarction — commonly known as a heart attack — is still one of the main causes of death. According to the Federal Statistical Office, more than 49,00 people died of its consequences. And yet the mortality after heart attack has greatly decreased over the past decades: As compared to the early 1990s, it has […]
Rituximab plus lenalidomide effective in follicular lymphoma
(HealthDay)—Rituximab plus lenalidomide has similar efficacy to rituximab plus chemotherapy among patients with previously untreated follicular lymphoma, according to a study published in the Sept. 6 issue of the New England Journal of Medicine. Franck Morschhauser, M.D., Ph.D., from the University of Lille in France, and colleagues conducted an international, randomized phase 3 trial to […]