There have been concerns that several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have mutations that allow them to evade the immune system. A new study published in the Open Forum Infectious Diseases suggests otherwise. Led by Aaron AR Tobian of Johns Hopkins University School of Medicine, results showed that except for one from […]
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Gene therapy overcomes mutation problems in cystic fibrosis
A team of researchers affiliated with multiple institutions in Germany has developed a type of gene therapy that could be used to help people with cystic fibrosis. In their paper published in the journal Nature Nanotechnology, the group describes how they developed a new class of non-viral gene vectors that could be used to reduce […]
Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans
In a recent report made available on bioRxiv* preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process. Study: Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans. Image Credit: An inspiration / Shutterstock Even before […]
Researchers explore how N501Y mutation in SARS-CoV-2 increases viral transmissibility
Researchers at Erasmus University Medical Center in The Netherlands have explored how and why new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), have exhibited heightened infectivity. Study: Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants. Image Credit: Design_Cells / Shutterstock They suggest […]
Mutation mechanism discovered for neuroendocrine pancreatic cancer
Although neuroendocrine tumors of the pancreas are rare, the available treatment options are currently limited. Researchers have now managed to identify the mutation mechanism, namely a mutation on the gene that activates the telomerase enzyme TERT, and this will potentially give rise to new treatment options. This discovery could lead to a more targeted treatment […]
NUP160 genetic mutation linked to steroid-resistant nephrotic syndrome
Mutations in the NUP160 gene, which encodes one protein component of the nuclear pore complex nucleoporin 160 kD, are implicated in steroid-resistant nephrotic syndrome, an international team reports March 25, 2019, in JASN. Mutations in this gene have not been associated with steroid-resistant nephrotic syndrome previously. “Our findings indicate that NUP160 should be included in […]
Ashkenazi Jewish founder mutation identified for Leigh Syndrome
Over 30 years ago, Marsha and Allen Barnett lost their sons to a puzzling childhood disease that relentlessly attacked their nervous systems and sapped their energy. After five-year-old Chuckie died suddenly in 1981, doctors provided a name for the disease: Leigh syndrome. Leigh syndrome is a complex disorder typically caused by dysfunctional mitochondria, the tiny […]
TGFB1 mutation ups radiation-induced breast fibrosis risk
(HealthDay)—The C-509T allele in the promoter region of transforming growth factor β (TGFB1) is associated with radiation-induced breast fibrosis risk among patients with early-stage breast cancer, according to study published online July 19 in JAMA Oncology. Aaron J. Grossberg, M.D., Ph.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues examined […]
CRISPR Gene Editing May Be Doing More Damage Than Scientists Thought
Like a molecular ninja, the genome-editing tool CRISPR-Cas9 slices through ultraspecific segments of DNA to cut out unwanted bits of genetic code. It's a precise and promising method of genetic editing that's widely used in scientific research. And scientists hope it could one day be used to selectively remove genes that result in medical problems […]