The STEP 5 clinical trial extends favorable weight loss from 1 year out to 2 years for the glucagon-like peptide-1 (GLP-1) agonist semaglutide (Wegovy, Novo Nordisk), given as a once-weekly 2.4-mg subcutaneous injection, and some food cravings were improved in a subgroup analysis. In another study, STEP 8, weight-loss was greater at 68 weeks with […]
Home »
Strong Support for Laws Against Weight Discrimination, Bullying
Dr Rebecca M. Puhl Although there are currently no national laws anywhere against weight-based discrimination or bullying, a survey of people engaged in weight management in six Western countries has found strong support for such laws and policies. Researchers surveyed adults enrolled in WW International (formerly Weight Watchers) in Australia, Canada, France, Germany, UK, and […]
Using Biochemistry to Fight Obesity
Obesity is the excessive accumulation of triacylglycerols in fatty tissue. This results from excessive calorie intake compared with expenditure. Obesity can rarely be attributed purely to genetic predisposition, though genes do play a polygenetic role in the propensity for an individual to store fat, grow muscle, engage in physical activity, and other metabolic processes. Image […]
Obesity Leads to Depression via Social and Metabolic Factors
New research provides further evidence that a high body mass index (BMI) leads to depressed mood and poor well-being via social and physical factors. Obesity and depression are “major global health challenges; our findings suggest that reducing obesity will lower depression and improve well-being,” co–lead author Jessica O’Loughlin, PhD student, University of Exeter Medical School, […]
Prenatal exposure to air pollutants may increase infants' obesity risk
Women exposed to higher levels of air pollution during pregnancy have babies who grow unusually fast in the first months after birth, putting on excess fat that puts them at risk of obesity and related diseases later in life, new CU Boulder research shows. The study of Hispanic mother-child pairs, published this week in the […]
DDT exposure in grandmothers linked to obesity, earlier periods in granddaughters
In the first study to report on the health effects of exposure to a toxic environmental chemical over three human generations, a new study has found that granddaughters whose grandmothers were exposed to the pesticide DDT have higher rates of obesity and earlier first menstrual periods. This may increase the granddaughters’ risk for breast cancer […]
Obesity reduces mitochondrial gene expression in fat tissue, finds study
A twin study recently completed at the University of Helsinki indicates that the machinery responsible for energy handling in fat tissue is working poorly in obesity. In the study, a clear reduction was seen in the activity of mitochondrial genes in obesity in fat tissue, while similar genome-level change in muscle mitochondria was minor. A […]
Pandemic effect: Healthcare experts warn of rise of obesity cases among children
Healthcare experts have said that the possible implications of COVID 19 in worsening the situation of overweight and obesity cannot be ignored. Confined to their homes amid the COVID-19 pandemic, children are facing a higher risk of obesity due to increased intake of junk food, lack of socialisation and physical activities, healthcare experts have warned. […]
Obesity a big risk factor for severe COVID-19, study confirms
(HealthDay)—Yet another study confirms what doctors have long known: Being obese greatly raises the odds that if you contract COVID-19, your case could be a severe one. The study, from researchers at the U.S. Centers for Disease Control and Prevention, supports calls for obese Americans to move to the head of the line for protective […]
3D microscopy sheds light on the body’s immune response to obesity
Researchers who focus on fat know that some adipose tissue is more prone to inflammation-related comorbidities than others, but the reasons why are not well understood. Thanks to a new analytical technique, scientists are getting a clearer view of the microenvironments found within adipose tissue associated with obesity. This advance may illuminate why some adipose […]