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Researchers have identified a cell communication pathway that controls cell growth and survival, and the finding could eventually help to develop treatments for diseases such as cancer and diabetes. Effective communication, crucial to human relationships, is also essential for the destruction of cancer cells within the body. In the body’s cells, communication involves the transmission […]
Researchers from Johns Hopkins University in collaboration with Insilico Medicine announce the publication of a new research paper titled “GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma” in Science Signaling. The KEAP1-NRF2 pathway plays a key role in cancer prevention and protective cellular responses to oxidative and electrophilic stress. In normal and premalignant tissues […]
A UC Davis study found that the damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus, was rapidly repaired within five hours of receiving Lactobacillus plantarum bacteria. The study, published today in the PNAS, linked chronically inflamed leaky gut to the loss of PPARα signaling […]
Close to 1.8 billion people worldwide are infected with Mycobacterium tuberculosis (Mtb), the common and occasionally deadly bacterium that causes millions of cases of tuberculosis each year. The bacteria, having coevolved with humans over millennia, have devised ways of hijacking nutrients from its human host for its own benefit. Humans have equally complex ways of […]
Small lipid vesicles known as extracellular vesicles are of great interest to cell scientists since it has been discovered that they mediate intercellular communication. Now, Professor Tom Carter’s group has identified a novel pathway for the storage and release of these vesicles from vascular endothelial cells. Working in collaboration with Dr Peter Rosenthal of the […]
Researchers from Singapore and South Korea have uncovered new details of a brain pathway that can cause impulsive behaviours. Using mice, the research team led by Professor George Augustine from Nanyang Technological University, Singapore (NTU Singapore), discovered that impulsive behaviour is triggered when the brain signalling chemical dopamine is passed to an unexpected area of […]
Researchers have made a significant new discovery concerning the signaling mechanisms that enable newts to regrow their tails after injury. Specifically, this process is shown to require the coordinated activation of the Hedgehog (Hh) and Wnt pathways. The study is published in Stem Cells and Development. Mary G. Garry, Daniel J. Garry, and colleagues from […]