Health News

JNK protein triggers nerve cells to withdraw their synapses when stressed

Synapses are tiny cell protrusions where electrochemical impulses pass between nerves. Prolonged stress in the brain causes synapse withdrawal and maladaptive changes to circuits that are linked to the development of major depressive disorder. Postdoctoral Researcher Patrik Hollós and colleagues used a light-activated optogenetic tool to switch off the activity of a protein called JNK […]

Health Problems

Protein progression in Barrett’s Esophagus disease

A study led by Nikhil Reddy, a second-year student at the Wright State University Boonshoft School of Medicine, has charted a protein’s decline through the progression of Barrett’s esophagus disease. The sickness, typically occurring after long-term acid reflux, is associated with a significant increase in the risk for esophageal cancer later in life. The protein, […]

Health Problems

Protein dynamics in the beating heart

The protein titin is a large structural component of the sarcomere—the machinery that mediates contraction of cardiac muscle cells. Despite its importance to the beating heart, little is known about titin turnover. Adrian Cadar, Ph.D., and colleagues have now used the microscopy technique FRAP (fluorescence recovery after photobleaching) to study titin dynamics in contracting cardiomyocytes. […]

Health News

Researchers describe a key protein for Epstein-Barr virus infection

Scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the Molecular Biology Institute of Barcelona (IBMB-CSIC) have published a study in the journal Nature Communications revealing the structure of a key protein, known as a portal, in Epstein-Barr virus infection. The Epstein-Barr virus, which belongs to the herpesvirus family, is one of the […]

Health Problems

Breaking down pathological protein aggregates

ETH researchers have discovered a new mechanism that brain cells use to protect themselves from protein aggregates. Such aggregates play a key role in Parkinson’s and other neurodegenerative diseases. This new finding might provide the basis for new therapeutic approaches. Aggregates of the protein alpha-synuclein in the nerve cells of the brain play a key […]