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ChIP-seq, or chromatin immunoprecipitation and sequencing, is a technique that allows researchers to understand transcriptional regulation via mapping of protein-DNA interactions and epigenetic markers on a genome-wide scale. ChIP-seq has several advantages over previous methods, such as ChIP-chip, but like all techniques, ChIP-seq has its limitations. urfin | Shutterstock ChIP-seq ChIP-seq was one of the […]
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry enables rapid profiling of various biomolecules from both tissues and biofluids. Rost9 | Shutterstock Although MALDI was originally used for the analysis of peptides and proteins, it now plays an important role in biomarker discovery, genotyping, identification of microorganisms, lipidomic analysis, and metabolomics. Improvements in the selection of […]
Matrix-assisted laser desorption ionization (MALDI) mass spectrometry enables rapid profiling of various biomolecules from both tissues and biofluids. Rost9 | Shutterstock Although MALDI was originally used for the analysis of peptides and proteins, it now plays an important role in biomarker discovery, genotyping, identification of microorganisms, lipidomic analysis, and metabolomics. Improvements in the selection of […]
For the second time, cancer researchers at Vanderbilt have discovered a protein that—when genetically manipulated to impede it from interacting with a gene responsible for cancer genesis—effectively melts tumors in days. The article, “MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1,” was published in the journal eLife on […]
A new study by University at Buffalo researchers has revealed that the absence of a single interaction within a brain receptor reduces its activity. The discovery advances the understanding of how certain brain diseases arise, and could lead to developing precision medicines for treating them. The study was published Dec. 31 in Proceedings of the […]
For the brain to learn, retain memories, process sensory information, and coordinate body movements, its groups of nerve cells must generate coordinated electrical signals. Disorder in synchronous firing can impair these processes and, in extreme cases, lead to seizures and epilepsy. Synchrony between neighboring neurons depends on the protein connexin 36, an essential element of […]
Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumour immune response. The preclinical research, published today in Nature Immunology, suggests that […]
Laboratory research and analysis of epidemiological data by Silvia Corvera, MD, and Tiffany Moore Simas, MD, MPH, MEd, and colleagues show that low levels of a protein commonly seen in screening tests for chromosomal disorders during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes mellitus in pregnant […]
A new University of Colorado Boulder-led study sheds light on a protein key to controlling how cells grow, proliferate and function and long implicated in tumor development. The findings, published this week in the journal Genes and Development, could lead not only to new therapies for hard-to-treat cancers, but also inform novel treatments for neurological […]
Hypertrophic cardiomyopathy is the most common inherited heart disease, marked by an abnormally thickened heart muscle that can obstruct blood flow and lead to sudden death in young adults. A dizzying array of over 1,400 genetic mutations can lead to the disease, puzzling doctors on how to treat so many unique varieties. But in new […]