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Sickle cell disease (SCD) is caused by a single genetic mutation yet displays significant clinical heterogeneity and many diagnostic challenges remain. Furthermore, current treatment options remain limited, and often complications associated with SCD make treatment difficult. Thus, there remain many notable challenges in SCD across the world. Sickle Cell Anemia. Image Credit: Meletios Verras/Shutterstock.com Clinical […]
Rare diseases are sometimes the most difficult to treat because of a lack of research and fewer participants to study. An example would be those who have Pompe disease, a genetic condition when a body can’t make a protein that breaks down a complex sugar, called glycogen, for energy. Too much glycogen builds up and […]
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India on Sunday banned the export of remdesivir as infections soared to a new daily high and hospitals grappled with increasing demand for the coronavirus treatment drug. The vast nation has experienced a sharp rise in cases in recent weeks, adding 152,000 new cases on Sunday to take the toll to 13.3 million infections. The […]
Many people with Parkinson’s disease develop abnormal movements called L-DOPA induced dyskinesia, a major side effect of long-term medication. The mechanism underlying this side effect has been unknown. In this study, researchers have revealed relation between changes of neuronal activities and dyskinesia. Parkinson’s disease (PD) is the common age-related neurological disorder affecting 7-10 million people […]
New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune system mistakenly attacks the body’s own joint tissues. Published in the journal Arthritis & Rheumatology, the discovery could […]
Cholinesterase inhibitors are a group of drugs recommended for the treatment of Alzheimer’s disease, but their effects on cognition have been debated and few studies have investigated their long-term effects. A new study involving researchers from Karolinska Institutet in Sweden and published in the journal Neurology shows persisting cognitive benefits and reduced mortality for up […]
From chemotherapy drugs that affect the whole body to very precise surgery to remove a tumor, different cancers require different treatments. One treatment that has been used for over a century is radiotherapy, which involves the use of high energy photons—such as X-rays or gamma rays. Rather than subjecting the entire body to treatment, this […]
An RCSI study conducted in Beaumont Hospital in Dublin has found that surgery, rather than antibiotics-only, should remain as the mainstay of treatment for acute uncomplicated appendicitis. Published in the Annals of Surgery and led by researchers from the RCSI University of Medicine and Health Sciences, the study entitled the COMMA trial (Conservative versus Open […]
Out-of-hospital cardiac arrests triggered by opioid overdose are a significant cause of death among adults 25 to 64, according to a scientific statement from the American Heart Association, the nation’s largest voluntary health organization focused on heart and brain health for all. The statement published today in the Association’s flagship journal Circulation. In the U.S., […]