Usually, it is assumed that a full stomach gives a feeling of satiety and we stop eating. Experiments on mice show, however, that the elongation of the intestine plays a much larger role in appetite regulation.
A large network of nerve endings monitors the contents of the stomach and intestines and sends signals to the brain that increase appetite or reduce. So far, but did not know exactly how this works. Researchers at the University of California in San Francisco have skin different types of Nerve cells in the mucous membrane and the muscles of the stomach and intestines are stimulated and found that mice with an activation of neurons that perceive a stomach strain, eat stop. The big Surprise was that the stimulation of stretch receptors in the gut is impaired, the appetite of the hungry mice are much stronger than in the stomach.
Not the stomach but the intestine makes für a Sättigungsgefühl
"This came quite unexpected, because the Dogma in this field is since decades that gastric stretch receptors, the volume and the receptors for the gut hormones the energy content of the consumed food messen", study leader Dr. Ling Bai said.
The results could also help explain why stomach reductions, which are performed for the treatment of severe obesity, reduce the long-term the appetite and Slimming promote: The fast in the intestine, the food could enable the strain sensors in there and the food intake inhibit. "Currently this idea is, however, a hypothesis yet to be tested muss", study author Prof. Dr. Zachary Knight said.
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