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Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer’s disease brains. The study, published today in Nature, reveals for the first time how the Alzheimer’s-linked gene, APP, is recombined by using the same type of enzyme found in HIV. Using […]
Researchers at the University of Helsinki have discovered a mechanism by which harmful tau protein aggregates are transmitted between neurons. Alongside amyloid plaques, tau aggregates in the brain are a significant factor in the progression of Alzheimer’s disease. Alzheimer’s disease is associated with two neuropathologies: amyloid plaques and tau aggregates, or tau protein accumulated in […]
Pioneering research into the mechanisms controlling gene activity in the brain could hold the key to understanding Alzheimer’s disease and might help identify effective treatments in the future. An international research team led by scientists at the University of Exeter and the University of Essex have uncovered a link between indicators of gene activity and […]
For older adults, it may seem as though the die is already cast regarding their odds of developing dementia, but new research from the University of Pittsburgh has identified a dementia risk factor among older adults that should be modifiable even well into old age. The study, which draws on data collected from following hundreds […]
Lack of sleep during adolescence and early adulthood accelerates Alzheimer’s disease (AD)-related tau pathology, finds a study of male and female mice published in JNeurosci. These results support the importance of establishing healthy sleep habits in early adult life to help stave off progression of neurodegenerative diseases. Using a mouse model of tauopathy, Sigrid Veasey […]
Helping hand from Downton creator on my luvvie night out: BONNIE ESTRIDGE on how Alzheimer’s is portrayed in the media It has been quite a month. My daughters, Hannah and Suzy, both in their 30s now, and I have just come back from a mainly glorious five days in Poland. I’ve always wanted to visit […]
With all the focus on Alzheimer disease in recent years as a result of the aging population, what have we learned? A symposium at The North American Menopause Society (NAMS) Annual Meeting in San Diego, October 3-6, will not only review conflicting evidence regarding the best way to diagnose the disease, but also the latest […]
Rutgers researchers have discovered a new mechanism that may contribute to Alzheimer’s disease and traumatic brain injury. They now hope to launch a clinical trial to test the treatment in humans. What causes Alzheimer’s is unknown, but a popular theory suggests a protein known as amyloid-beta slowly builds up a plaque in the brains of […]
The results of a large-scale international study involving the treatment of Alzheimer’s disease, which was led and coordinated by researchers at Trinity College Dublin, have just been published this week in a major medical journal, PLOS Medicine. Alzheimer’s disease, the commonest form of dementia, currently affects approximately 34 million people worldwide, with 10.5 million people […]
New research from USC has uncovered a previously unknown genetic risk factor for Alzheimer’s disease and related dementias. The study provides insights on how these conditions, and other diseases of aging, might one day be treated and prevented. The research from the Cohen Lab at the USC Leonard Davis School of Gerontology sheds new light […]