A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor. Such a biopsy can detect lingering disease and could serve as a guide for […]
Freiburg immunologists decipher anti-cancer drug's mode of operation
Rituximab, an anti-cancer drug targeting the membrane protein CD20, was the first approved therapeutic antibody against B tumor cells. Immunologists at the University of Freiburg have now solved a mystery about how it works. A team headed by Professor Dr. Michael Reth used cell cultures, healthy cells, and cells from cancer patients to investigate how […]
Constipation in the Elderly
The elderly are five times more likely than younger adults to develop problems related to constipation. Causes of constipation in the elderly Some of the reasons for this propensity include poor diet, lack of adequate fluids in diet, lack of exercise, the use of certain drugs to treat other medical conditions, and poor bowel habits. […]
The Importance of Spotting Leukemia
By Keynote ContributorDr. Mary Frances McMullinProfessor of Clinical Haematologyat Queens University, Belfastand Consultant Haematologistat Belfast City Hospital By Dr. Mary Frances McMullin, Professor of Clinical Haematology at Queens University, Belfast and Consultant Haematologist at Belfast City Hospital The majority of people have heard of the term leukemia, but evidence suggests many people are not aware […]
Why Cryo-EM is Gaining Popularity in Structural Biology
By Shelley Farrar, MSc, BSc Cryo-electron microscopy, also known as Cryo-EM, is a technique for visualizing macromolecular structures which has been developed over the last two decades. It is a form of transmission electron microscopy which permits samples to be studied at cryogenic temperatures. Biological structures such as ribosomes and mitochondria from pathogens, ion channels […]
Vulval Intraepithelial Neoplasia Treatment and Outcomes
Vulvar intraepithelial neoplasia (VIN) is a pre-cancerous condition caused by a rapid increase in atypical basal cells in the vulvar epithelium. Treatment is suggested for all vulvar HSIL (VIN usual type) affected women. Credit: Pr Image Factory/ Shutterstock.com Due to possible occurrence of occult invasion and when there exists a doubt about the presence of […]
The Cancer Cell Surface Proteome as a Therapeutic Target
The study of cell surface proteomics has led to a growth in knowledge of how this family of proteins function, what their structure is like, what modifications they undergo before and after translation, and more. This information is critical to the formation of disease, such as cancer. Image Credits: petarg / Shutterstock.com Recent studies have […]
Testosterone Replacement Therapy for Men: Risks and Benefits
Skip to: What is Testosterone Replacement Therapy? What are the Benefits of TRT? What are the Risks of TRT? Testosterone plays a vital role in the human body. Its effects increase muscle and bone strength and density, induce hematopoiesis, and drive libido and sexual function. Testicular production of testosterone typically declines with age, which can […]
Lung Cancer and Nail Clubbing
Nail clubbing is characterized by specific changes around and under the toe and fingernails that are caused by certain diseases. Lung cancer is the most frequent cause of nail clubbing. Image Credit: Douglas Olivares/Shutterstock.com What is nail clubbing? Nail clubbing, also called digital clubbing or Hippocratic nail, is primarily caused by an overgrowth of connective […]
Tumorsphere Formulation and Use in Cancer Stem Cell Research
Skip to: What are tumorspheres? Tumorsphere formation assay Technical notes on tumorsphere cultivation What are the types of cancer stem cell (CSC) tumorspheres? Tumorspheres for screening anti-CSC drugs What is the future of tumorspheres? What are tumorspheres? Numerous studies have pointed out that cancer stem cells (CSCs) play an important role in cancer progression, metastasis, […]