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THURSDAY, Aug. 16, 2018 — HIV, the virus that causes AIDS, is typically a manageable infection, but medications that keep the virus at bay don’t work for everyone. Now, researchers have developed a new medication to help them. The U.S. Food and Drug Administration approved the drug — ibalizumab (Trogarzo) — in March. Phase 3 […]
Investigators have discovered that arsenic in combination with an existing leukemia drug work together to target a master cancer regulator. The team, led by researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC), is hopeful that the discovery could lead to new treatment strategies for diverse types of cancer. Their findings were […]
About 50 percent of people who reach the age of 85 will develop Alzheimer’s disease. Most will die within about five years of exhibiting the hallmark symptoms of the disease – severe memory loss and a precipitous decline in cognitive function. But the molecular processes that lead to the disease will have begun years earlier. […]
THURSDAY, July 26 — There have been many setbacks on the long road to finding a treatment that might slow or stop Alzheimer’s disease, but a new trial offers a glimmer of hope. Researchers report that an experimental drug called BAN2401 slowed mental decline by as much as 30 percent in Alzheimer’s patients. It also […]
(HealthDay)—There have been many setbacks on the long road to finding a treatment that might slow or stop Alzheimer’s disease, but a new trial offers a glimmer of hope. Researchers report that an experimental drug called BAN2401 slowed mental decline by as much as 30 percent in Alzheimer’s patients. It also appeared to clear away […]
A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows. The discovery that the NOTCH1 pathway takes control of heat shock transcription factor 1 (HSF1) signaling in T cell acute lymphoblastic leukemia, or […]
Swiss pharmaceutical giant Novartis said Wednesday it would not hike drug prices in the United States this year, following a similar decision by rival Pfizer amid pressure from the White House. “We don’t plan to take any further price increases in the United States for 2018,” Novartis chief executive Vas Narasimhan told journalists on an […]
Scientists from the University at Buffalo in New York find that the receptor muscarinic type 3 (M3R) is a “key regulator” of remyelination, which is the process that replenishes lost myelin. M3R is found on the surface of oligodendrocyte progenitor cells (OPCs), the precursors to the cells that make myelin. A receptor is a cell-surface […]
There is a highly sophisticated way to treat some breast and ovarian cancers—a class of drugs called PARP inhibitors, designed to exploit the very defects that make tumors with certain mutations especially deadly. Yet this targeted approach to cancer therapy sometimes fails, and scientists have anxiously sought to understand why. Now, research at The Rockefeller […]
River blindness and elephantiasis are debilitating diseases caused by parasitic worms that infect as many as 150 million people worldwide. They are among the “neglected tropical diseases” for which better treatments are desperately needed. But they were far from the mind of cell biologist William Sullivan when he began studying the microbial parasite Wolbachia, best […]