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One in every 15,000 children is affected by Prader-Willi syndrome (PWS), a complex, genetic endocrine condition caused by a disorder of chromosome 15. It’s non-inheritable, meaning the condition isn’t passed down from a family member. Among the regular side effects like growth hormone deficiency, hypothyroidism, delayed puberty, behavioral problems and learning difficulties, but hyperphagia is […]
An investigational cancer drug that targets tumors caused by mutations in the KRAS gene will be evaluated in phase 2 clinical trials, following promising safety and efficacy results in preliminary human studies and excellent results in animal studies. The drug, developed by Amgen and currently referred to as AMG 510, is the first therapy to […]
Measuring changes in the speed of electrical signals along nerves connecting the eyes to the brain may accurately reflect recovery from myelin loss in multiple sclerosis (MS), according to researchers at the University of Wisconsin-Madison, and could be used to evaluate new treatments for the disease. Most MS patients develop a relapsing-remitting disease, in which […]
Among the numerous microengineered Organ-on-a-Chip (Organ Chip) models developed at the Wyss Institute, the Liver Chip is of special interest to a number of industries because the real-time analysis of complex biochemical interactions could greatly enhance the liver toxicity testing that is ubiquitous in the development of drugs, foods, and other consumer products. The Wyss […]
Demi Lovato revealed on Instagram that her friend Thomas died this week of a drug overdose. She reminded fans that “addiction is NO joke” in her post. Demi has been through her own public struggles with addiction over the past few years. Demi Lovato shared a sad update with fans on Instagram: Her friend Thomas […]
A new preclinical study by University at Buffalo researchers reveals the genetic basis of relapse, one of the most detrimental but poorly understood behaviors related to addiction. Craig Werner, Ph.D., is first author on a paper published Oct. 9 in Science Advances that demonstrates how prolonged abstinence after cocaine use drives gene changes that promote […]
Hope for thousands of prostate cancer sufferers as trial finds a ‘precision’ drug can help incurable patients live almost four months longer Lynparza extended survival of men with advanced prostate cancer by 7.4 months That is more than double the NHS hormonal treatments (3.5 months) Lynparza works by targeting faulty DNA which helps cancer cells […]
Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new drug delivery pathway that may help stop tumor growth and keep cancer from coming back in mice. In the preclinical study, the team found that they could reengineer adipocytes—fat cells that feed fatty acids energy needed to promote tumor growth and metastasis—to reverse […]
NHS agrees to pay for a ‘trailblazing’ drug that prevents deadly bleeds in patients with severe haemophilia Severe haemophilia A is thought to affect around 1,800 people in the UK Patients were forced to have clotting drugs administered into vein in chest Drug emicizumab can be injected under the skin as little as every two weeks […]
(HealthDay)—The number of foster care entries attributable to parental drug use increased considerably from 2000 to 2017, according to a research letter published online July 15 in JAMA Pediatrics. Angélica Meinhofer, Ph.D., from Weill Cornell Medical College in New York City, and Yohanis Angleró-Díaz, M.D., from Harvard Medical School in Boston, analyzed data from the […]