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MONDAY, Nov. 19, 2018 — Drug approvals for adults often require future studies in children, but many of these studies are never completed, a new analysis finds. “More than 50 percent of all drugs approved by the FDA lack information on how to safely and effectively use the drug in children,” said study author Dr. […]
‘Trojan horse’ antibiotic can kill drug-resistant superbugs from WITHIN ‘by hijacking their defences’ The drug, called cefiderocol, works by attaching itself on to iron molecules Once allowed inside the bacterial cell, it can destroy it from within, experts say Experts now hope it will top up the world’s dwindling arsenal of antibiotics Antibiotic resistance is […]
Researchers have discovered that inhibiting CDK9, a DNA transcription regulator, reactivates genes that have been epigenetically silenced by cancer. Reactivation leads to restored tumor suppressor gene expression and enhanced anti-cancer immunity. It is the first time this particular kinase has been linked to gene silencing in mammals. Jean-Pierre Issa, MD, Director of the Fels Institute […]
Some drugs for heart disease might also work against brain cancer, according to an analysis by researchers from the Jackson Laboratory (JAX), Connecticut Children’s Medical Center (CCMC), and UConn Health. The researchers used a new approach to identify five heart medicines that might also be effective at fighting the most common type of childhood brain […]
A drug could help slow the progression of some advanced ovarian cancers and extend the time that patients show no signs of disease, according to new clinical trial results. The study, published in the New England Journal of Medicine, found that the drug olaparib (Lynparza) could delay the return of advanced ovarian cancer in some […]
World first as experimental drug appears to REVERSE symptoms in girl, 7, with incurable disease that causes paralysis, blindness, dementia and early death Mila Makovec, from Boulder, Colorado, was born happy and healthy, but soon she developed a stutter, had trouble walking, and became blind At age six, Mila was diagnosed with Batten disease – […]
Running low on oxygen is a major danger for any of your body’s tissues, but the heart is particularly sensitive to such hypoxic conditions, which can lead to long-term tissue damage or even heart attacks. In new studies conducted at UC San Francisco, a novel oxygen-delivery therapeutic restored the function of oxygen-starved heart tissue in […]
MONDAY, Oct. 1, 2018 — Arikayce (amikacin liposome inhalation suspension) has been approved by the U.S. Food and Drug Administration to treat lung disease caused by Mycobacterium avium complex (MAC) bacteria among patients who do not respond to conventional therapies, the FDA said in a news release. MAC bacteria are commonly found in water and […]
From the DNA of nearly 300,000 veterans, scientists have singled out a handful of genetic mutations that not only govern levels of cholesterol, but may also inform the development and use of drugs for cardiovascular disease and diabetes, according to researchers at the Stanford University School of Medicine and the Palo Alto Veteran Affairs Health […]
The results of a large-scale international study involving the treatment of Alzheimer’s disease, which was led and coordinated by researchers at Trinity College Dublin, have just been published this week in a major medical journal, PLOS Medicine. Alzheimer’s disease, the commonest form of dementia, currently affects approximately 34 million people worldwide, with 10.5 million people […]