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The arachnoid is one of the three meninges, or brain membranes, and is responsible for mechanically and immunologically protecting the brain and the spinal cord. It allows communication between the cerebrospinal fluid (which bathes the brain and the spinal cord) and the cerebral blood vessels, and controls several crucial physiological responses in the brain, such […]
Researchers launch clinical trial to see if aspirin could treat aggressive breast cancer when paired with immunotherapy Researchers are testing aspirin on patients with triple negative breast cancer The trial is the first to test if drug can make tumours sensitive to immunotherapy Successful results could lead to further clinical trials of aspirin and avelumab […]
Gaurav Gaiha, MD, DPhil, a member of the Ragon Institute of MGH, MIT and Harvard, studies HIV, one of the fastest-mutating viruses known to humankind. But HIV’s ability to mutate isn’t unique among RNA viruses—most viruses develop mutations, or changes in their genetic code, over time. If a virus is disease-causing, the right mutation can […]
Since 2008, we have known that the 16p11.2 chromosomal region is linked with autism spectrum disorder (ASD). Now, researchers from Boston Children’s have developed a new way to study the effects of 16p11.2 deletion in human neurons. In the process, they also found a potential treatment, possibly expanding the therapeutic options for this specific cause […]
Lyme disease has the potential to emerge in a wider range of habitats than previously thought, suggests University of Liverpool and University of Glasgow research. A new study, published in Emerging Infectious Diseases found that open, treeless habitats can support similar densities of infected ticks as woodland in the UK, challenging established knowledge of which […]
Brazilian researchers who study a native venomous fish have confirmed a route to drug development for the treatment of chronic inflammatory diseases such as multiple sclerosis and asthma. The venomous toadfish Thalassophryne nattereri contains a peptide (TnP) with anti-inflammatory and anti-allergic potential. Confirmation of this potential has now come via the zebrafish Danio rerio, a […]
Using a novel technology Griffith University Institute for Glycomics researchers are closer to the development of a new vaccine aimed at preventing the deadly Streptococcus A (strep A), which kills more than 500,000 people globally per year. “Strep A colonizes the upper respiratory tract and skin. Repeated infections can cause auto-immune complications and progress to […]
As reported in Nature Communications, researchers from Cleveland Clinic’s Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease. The team used the model to identify a promising target that could be inhibited to slow disease progression.Ulcerative colitis is […]
A new study by researchers in Cleveland Clinic’s Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia. The results first appeared online in Blood Cancer Discovery. Myeloid leukemias are cancers derived from stem and progenitor cells in the […]
Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment, according to a study in the journal Neuron. LOAD is the most prevalent form of dementia among people over age 65, a […]