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Antibodies are central to infection control and prolonged immunity. Key tools in biomedical research, antibodies are also used to diagnose human diseases and detect adaptive immunity to past infections with particular pathogens. While existing methods to discover and generate antibodies are successful, they also have important limitations, such as hard targets (short-lived, homologous, or unstable) […]
Apoptosis is a form of programmed cell death, which occurs in cells that are irreparably damaged or in cells infected by some viruses. This mechanism is extremely important in limiting a virus’s replication and its spread to other neighboring cells. A new paper in the journal Life presents an early review of the viral factors […]
Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the T-Detect COVID Test developed by Adaptive Biotechnologies. The T-Detect COVID Test is a next generation sequencing based (NGS) test to aid in identifying individuals with an adaptive T cell immune response to SARS-CoV-2, indicating recent or prior infection with SARS-CoV-2. […]
A team of researchers led by a group at the Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, has found evidence suggesting that the U.K. variant of the SARS-CoV-2 virus could be 43 to 90% more transmissible than the original virus. In their study, published in the journal Science, […]
The global spread of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to intense interest in the various manifestations of the infection, including its neurological features. A compact summation by researchers across the UK of what is known at present about this facet of the […]
Researchers at Erasmus University Medical Center in The Netherlands have explored how and why new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), have exhibited heightened infectivity. Study: Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants. Image Credit: Design_Cells / Shutterstock They suggest […]
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has largely defied attempts to contain its spread by non-pharmaceutical interventions (NPIs). With the massive loss of life and economic damage, the only way out, in the absence of specific antiviral therapeutics, has been the development of […]
Epidemiological models have been indispensable in aiding our understanding of the unfolding coronavirus disease 2019 (COVID-19) pandemic. A team of international scientists has recently developed an epidemiological model to explore the impact of individual variation in susceptibility and infectivity on transmission dynamics of an infectious disease across inhomogeneous populations. The study is currently available on […]
In late-December 2019, the coronavirus disease 2019 (COVID-19) was first detected in Wuhan City, China, causing an easily transmissible respiratory illness. By March 2020, the World Health Organization (WHO) declared its outbreak a global pandemic. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 has infected over 107.48 million people globally. To date, […]
Back in 1892, Doderlein first established the beneficial association of microorganisms in the human body. Therefore, under the COVID-19 pandemic, it can be beneficial to assess microorganisms' role in the human body and the use of probiotics as therapy for COVID-19 patients. While the term "microbiome" (coined by the Nobel laureate Joshua Lederberg, 2001) includes […]