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Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed? Keshav Singh, Ph.D., and colleagues have done just that, in a mouse model developed at the University of Alabama at Birmingham. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss […]
There is a highly sophisticated way to treat some breast and ovarian cancers—a class of drugs called PARP inhibitors, designed to exploit the very defects that make tumors with certain mutations especially deadly. Yet this targeted approach to cancer therapy sometimes fails, and scientists have anxiously sought to understand why. Now, research at The Rockefeller […]
Hope for menopausal women: Scientists discover a way to banish hot flashes without raising a woman’s stroke risk Scientists have shown we could target a neuron rather than estrogen levels with drugs Hormone replacement therapy reduces hot flashes but increases stroke risk Hot flashes are the most commonly-discussed symptom of menopause. And yet, despite years […]
Scientists have discovered a “Big Bang” of Alzheimer’s disease – the precise point at which a healthy protein becomes toxic but has not yet formed deadly tangles in the brain. A study from UT Southwestern’s O’Donnell Brain Institute provides novel insight into the shape-shifting nature of a tau molecule just before it begins sticking to […]
Researchers have recently begun to realize that biological sex plays a key role in disease risk. Sex plays a role in hypertension, diabetes, arthritis—and in many neurological and psychiatric disorders. Depression and anxiety affect females more, while neurodevelopmental disorders, including autism spectrum disorders, early onset schizophrenia, and attention deficit hyperactivity, affect more males. Males are […]
Old before your time? Scientists have put together five warning signs middle-aged people will suffer from frailness in retirement Being inactive, obese and a smoker are the three biggest causes of frailness Having high levels of proteins that mark inflammation also boost the risk Living alone in middle age almost doubles the risk of frailty […]