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A new study led by Hans-Martin Jäck of the Friedrich-Alexander University Erlangen-Nuremberg in Germany engineered clusters of neutralizing monoclonal antibodies using a transgenic mouse model. A unique characteristic for the antibodies was the different ways it bound to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the overall reduction in the viral spread for […]
The alarmingly high infection rate of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the coronavirus 2019 (COVID-19) pandemic, has had an enormous impact on healthcare in many parts of the world. The surge in the rate of hospitalization, especially intensive care unit admissions, has placed an overwhelming burden on healthcare systems […]
When a virus invades an individual, both innate and adaptive immunity play crucial roles. The successful viral pathogens can antagonize these immune pathways with genes that inhibit the key players in the immune system. The coronavirus disease 2019 (COVID-19) pandemic is caused by the novel beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It […]
In a recent report posted to the bioRxiv* preprint server, researchers from the United Kingdom and Uganda reveal unique protein features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to other representatives of Sarbecoviruses. The causative agent of the coronavirus disease 2019 (COVID-19), SARS-CoV-2, belongs to the Betacoronavirus genus and Sarbecovirus subgenus of the […]
There have been concerns that several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have mutations that allow them to evade the immune system. A new study published in the Open Forum Infectious Diseases suggests otherwise. Led by Aaron AR Tobian of Johns Hopkins University School of Medicine, results showed that except for one from […]
The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown. Researchers from Brigham and Women's Hospital, Massachusetts General Hospital (MGH), and the Broad Institute […]
In a recent report made available on bioRxiv* preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process. Study: Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans. Image Credit: An inspiration / Shutterstock Even before […]
Many cognitive neurodevelopmental disorders are a result of too many or too few copies of certain genes or chromosomes. To date, no treatment options exist for this class of disorders. MECP2 duplication syndrome (MDS) is one such disorder that primarily affects boys and results from a duplication spanning the methyl-CpG binding protein 2 (MECP2) locus […]
The global spread of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to intense interest in the various manifestations of the infection, including its neurological features. A compact summation by researchers across the UK of what is known at present about this facet of the […]
Researchers at Erasmus University Medical Center in The Netherlands have explored how and why new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), have exhibited heightened infectivity. Study: Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants. Image Credit: Design_Cells / Shutterstock They suggest […]