Acute kidney injury (AKI)—sudden and rapid failure of the kidneys—affects up to 20 percent of hospitalized patients, and up to 70 percent of ICU patients.
Studies have indicated that dedifferentiation and proliferation of surviving kidney cells contributes to kidney regeneration and recovery from AKI. EGF receptor (EGFR) and Hippo signaling pathways, which regulate cell proliferation and death, are important to this process.
Now, Jianchun Chen, MD, Raymond Harris, MD, and colleagues report in the Journal of the American Society of Nephrology that YAP, a key effector of the Hippo signaling pathway, is involved in AKI recovery.
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