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The coronavirus disease (2019) pandemic arose due to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the farthest corners of the world, leaving large numbers of deaths in its wake. Vaccination has emerged as a beacon of hope for the human population to escape this high-level threat to global health and […]
A study published this May in the journal Clinical Infectious Diseases suggests that people who have had dengue in the past are twice as likely to develop symptoms of COVID-19 if they are infected by the novel coronavirus. The findings of the study were based on an analysis of blood samples from 1,285 inhabitants of […]
In the setting of potentially reduced vaccine efficacy against coronavirus disease (COVID-19) due to emerging viral variants, the deployment of effective treatments based on monoclonal antibodies may be an additional strategy to help control the pandemic. A new study by US researchers, currently available on the bioRxiv* preprint server, describes the action of a specific […]
A new study led by Hans-Martin Jäck of the Friedrich-Alexander University Erlangen-Nuremberg in Germany engineered clusters of neutralizing monoclonal antibodies using a transgenic mouse model. A unique characteristic for the antibodies was the different ways it bound to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the overall reduction in the viral spread for […]
When a virus invades an individual, both innate and adaptive immunity play crucial roles. The successful viral pathogens can antagonize these immune pathways with genes that inhibit the key players in the immune system. The coronavirus disease 2019 (COVID-19) pandemic is caused by the novel beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It […]
As COVID-19 has swept across the globe, it seems that high transmission rates have partly been driven by a large number of people catching the virus, not experiencing symptoms and then unknowingly passing it on. Despite this, the screening of asymptomatic people for signs of infection hasn’t been widespread, due to costs and limits on […]
IONTAS Limited (IONTAS) and FairJourney Biologics S.A (FJB)., leaders in the discovery and optimization of fully human antibodies, have announced the identification of neutralizing antibodies, which bind to multiple emerging SARS-CoV-2 variants. The results, generated from a combination of phage display technology and B-cell receptor repertoire sequencing of hospitalized COVID-19 patients, have identified potent neutralizing […]
The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown. Researchers from Brigham and Women's Hospital, Massachusetts General Hospital (MGH), and the Broad Institute […]
Antibodies are central to infection control and prolonged immunity. Key tools in biomedical research, antibodies are also used to diagnose human diseases and detect adaptive immunity to past infections with particular pathogens. While existing methods to discover and generate antibodies are successful, they also have important limitations, such as hard targets (short-lived, homologous, or unstable) […]
Skip to: What is CVID? What is the prevalence of CVID? What are the causative factors? How CVID is inherited? What are the common symptoms? How is CVID diagnosed? How is CVID treated? Common variable immune deficiency (CVID) is a genetic disorder characterized by a weakened immune system. Patients with CVID frequently suffer from infections. […]