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A new study by members of the Cumming School of Medicine (CSM) at the University of Calgary finds niacin, commonly called vitamin B3, combined with chemotherapy can help immune cells attack glioblastoma (a type of brain tumor), dramatically slowing progression of the disease, in mice. The results published in Science Translational Medicine found the lifespan […]
The method of choice used for preparing tissue samples can lead to biased results in the analysis of cancer patient survival. For microscopical analysis, full tissue samples provide a better picture of the immune cell activity in the tumor compared to tissue-sparing punch biopsies. A team led by the visceral surgeon Elisabeth S. Gruber and […]
Scientists report promising activity of a novel drug that targets a key molecular driver of clear cell renal cell carcinoma in patients with metastatic disease. Researchers from Dana-Farber Cancer Institute report a response rate of 24 percent across all risk categories of patients given an oral first-in-class agent that targets hypoxia inducible factor (HIF) 2-a, […]
The benefits of a daily aspirin may extend beyond heart health to colorectal cancer treatment, say City of Hope researchers who have found aspirin appears to reduce tumor growth and inhibit recurrence of the disease. The trick now, researchers say, is to determine the right dosage of aspirin that can be used as a daily […]
It starts as a yellow or shiny bump on the eyelids, face or body that grows and doesn’t go away, unlike a pimple. The bump is sebaceous carcinoma, a cancer of the oil glands diagnosed in thousands of patients in the U.S. every year. If not removed and treated promptly, it can spread to other […]
The cover for issue 55 of Oncotarget features Figure 3, “Romidepsin exhibits anti-tumor effect in xenograft model of DDLPS,” by Seligson, et al. Here the researchers present in silico, in vitro, and mouse xenograft studies that suggest that specifically targeting HDAC2 reduces MDM2 expression and has anti-tumor affects in DDLPS. In a murine DDLPS xenograft […]
Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new drug delivery pathway that may help stop tumor growth and keep cancer from coming back in mice. In the preclinical study, the team found that they could reengineer adipocytes—fat cells that feed fatty acids energy needed to promote tumor growth and metastasis—to reverse […]
In a current paper published in the journal Nature, Heidelberg-based researchers and physicians describe how neurons in the brain establish contact with aggressive glioblastomas and thus promote tumor growth / New tumor activation mechanism provides starting points for clinical trials Neurons transmit their signals to each other via synapses, fine cell projections with terminals that […]
The pregnancy test was positive, her belly was round, you felt healthy, there was no indication that something could be wrong with Tammie and her Baby. However, at an ultrasound appointment in the 12. Week of shock Tammie was not at all pregnant, she had cancer. As Tammie Mylan holding her positive pregnancy test in […]
A computer-assisted diagnostic procedure helps physicians detect the growth of low-grade brain tumors earlier and at smaller volumes than visual comparison alone, according to a study published May 28 in the open-access journal PLOS Medicine by Hassan Fathallah-Shaykh of the University of Alabama at Birmingham, and colleagues. However, additional clinical studies are needed to determine […]